Simplakidine A,a unique pyridinium alkaloid from the Caribbean sponge plakortis simplex |
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| Authors: | Campagnuolo Claudio Fattorusso Caterina Fattorusso Ernesto Ianaro Angela Pisano Barbara Taglialatela-Scafati Orazio |
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| Affiliation: | Dipartimento di Chimica delle Sostanze Naturali, Dipartimento di Farmacologia Sperimentale, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy. |
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| Abstract: | ![]()
Simplakidine A, a unique 4-alkyl-substituted pyridiunium alkaloid, has been isolated from the Caribbean sponge Plakortis simplex. The stereostructure of simplakidine A has been determined using MS and NMR data, molecular mechanics, and an extension of the J-based configuration analysis. Data about the growth-inhibition activity of simplakidine A are reported. |
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