| 光动力化合物5-氨基乙酰丙酸的简便全合成 |
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| 引用本文： | 刘海灵,江焕峰,王玉刚,刘鹏.光动力化合物5-氨基乙酰丙酸的简便全合成[J].有机化学,2005,25(11):1431-1433. |
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| 作者姓名： | 刘海灵 江焕峰 王玉刚 刘鹏 |
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| 作者单位： | 1. 华南理工大学化学科学学院,广州,510640;中国科学院广州化学研究所,广州,510650;中国科学院研究生院,北京,100039
2. 华南理工大学化学科学学院,广州,510640 |
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| 摘 要： | 从γ-丁内酯出发, 首先发生醇解、氧化反应, 继而采用无溶剂法与硝基甲烷在KF/Al2O3催化下发生Henry反应, 再经湿Al2O3负载的CrO3氧化得到5-硝基-4-羰基戊酸乙酯, 最后在Pd/C催化下还原得到5-氨基乙酰丙酸. 各步所合成化合物的结构经1H NMR, IR, MS分析确证.
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| 关 键 词： | 光动力化合物 5-氨基乙酰丙酸 γ-丁内酯 Henry反应 全合成 |
| 收稿时间： | 11 24 2004 12:00AM |
| 修稿时间： | 05 8 2005 12:00AM |
Simple Total Synthesis of Photodynamic Compound 5-Aminolevulinic Acid |
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| LIU,Hai-Ling,JIANG,Huan-Feng,WANG,Yu-Gang,LIU,Peng.Simple Total Synthesis of Photodynamic Compound 5-Aminolevulinic Acid[J].Chinese Journal of Organic Chemistry,2005,25(11):1431-1433. |
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| Authors: | LIU Hai-Ling JIANG Huan-Feng WANG Yu-Gang LIU Peng |
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| Institution: | a.College of Chemistry, South China University of Technology, Guangzhou 510640;b.Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650;c.Graduate School of the Chinese Academy of Sciences, Beijing 100039 |
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| Abstract: | 5-Aminolevulinic acid (5-ALA) was prepared from γ-butyrolactone via alcoholysis, oxidation, Henry reaction, oxidation and hydrogenation. Especially Henry reaction was carried out through a solvent-free procedure in the presence of alumina supported potassium fluoride, and then oxidation of the nitroalkanol was finished using wet alumina supported chromium(VI) oxide. The structures of all the com-pounds were confirmed by 1H NMR, IR and MS spectra. |
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| Keywords: | photodynamic compound 5-aminolevulinic acid γ-butyrolactone Henry reaction total synthe-sis |
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