A one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from thioamides or thioureas and 2-chloro-1,3-dicarbonyl compounds in an ionic liquid |
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| Authors: | Issa Yavari S Zahra Sayyed-Alangi Rahimeh Hajinasiri Hadi Sajjadi-Ghotbabadi |
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| Institution: | (1) Chemistry Department, Science and Research Campus, Islamic Azad University, Ponak, Tehran, Iran;(2) Chemistry Department, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran |
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| Abstract: | Abstract A simple one-pot synthesis of functionalized ethyl 1,3-thiazole-5-carboxylates from the reaction of 2-chloro-1,3-dicarbonyl
compounds with thioureas or thioamides in the presence of 1-butyl-3-methylimidazolium trifluoromethanesulfonate is described.
Graphical abstract
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| Keywords: | Heterocyclic synthesis Ionic liquid Thiourea Thioamide |
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