Synthesis,structure, and urease inhibitory activities of Co(III), Mn(II) and Zn(II) complexes with hydrazone derived from protocatechuic acid |
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| Authors: | Cun-Fang Wang Zhi-Jian Chen Ke-Dong Zhao Xiang-Fei Chen Chun-Yang Zhang |
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| Institution: | School of Life Sciences, Shandong University of Technology, ZiBo, PR China |
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| Abstract: | CoIII(L1)2·H2O]NO3 (1), MnII(L1)2·H2O] (2), and ZnII(L1)2·H2O] (3) with a hydrazone derived from protocatechuic acid (HL1 = C15H13N3O3) were designed, synthesized, and characterized by C, H, N elemental analyses, single-crystal X-ray diffraction, and IR spectra, which revealed that the three complexes are similar structures. Docking study has been done. The urease inhibitory activities of the three complexes were tested. Complexes 1 and 3 showed strong inhibitory activity against jack bean urease with IC50 values of 45.9 and 11.64 μM. Complex 2 had no obvious inhibitory activity to urease; the IC50 was > 50 μM. |
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| Keywords: | Complex hydrazone urease inhibitors protocatechuic acid molecular docking |
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