Diversity-oriented expedient route for the synthesis of 3-tetrahydropyrimidinyl-coumarins via MCR |
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| Authors: | Vicky Jain Sabera Bijani Pratik Ambasana Krunal Mehariya Umed Bhoya Bipin Pandey |
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| Affiliation: | 1. National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot, Indiaanamik_shah@hotmail.com;3. National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot, India |
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| Abstract: | ![]()
A practical, mild, and high-yielding synthetic approach for the synthesis of unknown tetrahydropyrimidinyl substituted 3-coumarins as hybrid scaffolds, potentially useful new chemical entities (NCEs), via metal- and catalyst-free multicomponent cyclization is described. The enhanced nucleophilicity of 3-amino coumarins versus 4-amino coumarin is explained via the difference in 13C NMR δ values (Δδ) of vinylic carbons. X-ray crystal analysis defines the structure of a representative set of example. |
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| Keywords: | Catalyst-free 13C NMR and nucleophilicity Mannich reaction MCR tetrahydropyrimidinyl-coumarins |
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