One-pot multicomponent diastereoselective synthesis of novel dihydro-1H-furo[2,3-c]pyrazoles |
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| Authors: | Venkata Swamy Tangeti G. V. Siva Prasad Jagadeesh Panda K. Ramesh Varma |
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| Affiliation: | 1. Raghu Engineering College, Vishakhapatnam, Indiaswamychempcu8@gmail.com;3. Raghu Engineering College, Vishakhapatnam, India;4. Raghu College of Pharmacy, Vishakhapatnam, India;5. Sri Venkateswara University, Tirupathi, India |
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| Abstract: | An efficient method was developed for the diastereoselective synthesis of novel fused dihydro-1H-furo[2,3-c]pyrazole by a one-pot, four-component reaction of β-keto ester, hydrazine, aromatic aldehyde, and pyridinium ylide in the presence of triethylamine under microwave irradiation in solvent-free conditions in good yields. The merits of this cascade Knoevenagel condensation/Michael addition/cyclization sequence include its high atom economy, good yields, and efficiency of producing three new bonds (two C–C and one C–O) and two stereocenters in a single operation. |
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| Keywords: | Dihydrofuro[1,2-b]pyrazole microwave synthesis multicomponent solvent free |
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