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Diastereoselective synthesis of 2-oxiranyl and 2-aziridinyl thiazoles |
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| Authors: | Fabio BonaLuisella De Vitis Saverio FlorioLudovico Ronzini Luigino Troisi |
| Affiliation: | a Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Lecce, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy b Dipartimento Farmaco-Chimico, CNR ‘Istituto di Chimica dei Composti Organometallici—I.C.C.O.M.’, University of Bari, Via E. Orabona 4, 70125 Bari, Italy |
| Abstract: | 2-Chloroalkylthiazolyllithiums, prepared by deprotonating the 2-chloroalkylthiazoles with n-BuLi at −78°C in THF, add to ketones or imines affording in ‘one-pot’ oxiranes and aziridines in a Z stereoselective manner. |
| Keywords: | thiazolylalkyloxiranes thiazolylalkylaziridines carbanion nucleophilic addition |
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