Catalytic enantioselective alkynylation of prochiral sp3 C-H bonds adjacent to a nitrogen atom |
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| Authors: | Li Zhiping Li Chao-Jun |
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| Affiliation: | Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada. |
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| Abstract: | [reaction: see text] The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp3 and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method. |
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