New synthetic method for orsellic acid type macrolides by intramolecular alkylation of protected cyanohydrin. The synthesis of (±)-zearalenone. |
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| Authors: | Takashi Takahashi Hiroshi Ikeda Jiro Tsuji |
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| Affiliation: | Tokyo Institute of Technology, Meguro, Tokyo 152, Japan |
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| Abstract: | Zearalenone was synthesized by a general cyclization method of orsellic acid type macrolides having ketone moiety using the intramolecular alkylation of the protected cyanohydrin. This alkylation tolerates the presence of ester group and requires short reaction time. |
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