Synthesis and cyclodehydration of hydroxyphenols: a new stereoselective approach to 3-aryl-2,3-dihydrobenzofurans |
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| Authors: | Bertolini Ferruccio Crotti Paolo Di Bussolo Valeria Macchia Franco Pineschi Mauro |
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| Affiliation: | Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy pineschi@farm.unipi.it. |
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| Abstract: | ![]()
A novel and simple method for the stereoselective synthesis of substituted 3-aryl-2,3-dihydrobenzofurans by intramolecular cyclization of hydroxyphenols is described. The stereoselective ortho-C-alkylation of phenols allows a novel and stereoselective access to a diverse array of polyfunctionalized products containing a diarylmethane stereogenic center without the need for time-consuming protection-deprotection steps. |
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