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A new method for the synthesis of some 9-β-D-arabinofuranosylpurines by a combination of chemical and enzymatic reactions
Authors:Hirokazu Morisawa  Takashi Utagawa  Takeshi Miyoshi  Fumihiro Yoshinaga  Akihiro Yamazaki  Koji Mitsugi
Affiliation:Central Research Laboratories, Ajinomoto Co., Inc. 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, 210, Japan.
Abstract:
An enzymatic transarabinosylation between 2-chlorohypoxanthine and 1-β-D-arabinofuranosyluracil gave 9-β-D-arabinofuranosyl-2-chlorohypoxanthine which was chemically converted to 9-β-D-arabinofuranosylguanine and its derivatives.
Keywords:
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