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Construction of “normal”- and “iso-type” oxazolidine rings in C20-diterpenoid alkaloids: Oxidative cyclization with potassium ferricyanide
Authors:SWilliam Pelletier  Abdel-Monem M Ateya  Naresh V Mody  Haridutt K Desai  Lee C Schramm
Institution:Institute for Natural Products Research, the Department of Chemistry, and the School of Pharmacy The University of Georgia, Athens, Georgia 30602, U.S.A.
Abstract:An efficient and simple method using alkaline ferricyanide for converting the NCH2CH2OH group-containing alkaloid derivatives into their “normal”- and “iso-type”-oxazolidine ring-containing alkaloids has been developed. This is the first one-step oxidation method which affords both types of oxazolidine rings simultaneously.
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