Synthesis of primary amines: first homogeneously catalyzed reductive amination with ammonia |
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Authors: | Gross Thoralf Seayad Abdul Majeed Ahmad Moballigh Beller Matthias |
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Institution: | Institut für Organische Katalyseforschung (IfOK) an der Universit?t Rostock e.V., Buchbinderstrasse 5-6, D-18055 Rostock, Germany. |
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Abstract: | reaction: see text] The synthesis of primary amines via reductive amination of the corresponding carbonyl compounds with aqueous ammonia is achieved for the first time with soluble transition metal complexes. Up to an 86% yield and a 97% selectivity for benzylamines were obtained in the case of various benzaldehydes by using a Rh-catalyst together with water-soluble phosphine and ammonium acetate. In the case of aliphatic aldehydes, a bimetallic catalyst based on Rh/Ir gave improved results. |
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