A facile reaction involving zwitterionic intermediates for the synthesis of 5-hydroxy-2H-pyrrol-2-one derivatives |
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| Authors: | Ming-Jin Fan Lian-Biao Zhao |
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| Institution: | a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China
b State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China |
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| Abstract: | The reaction of cyclohexyl isocyanide with various aldehydes and 1,3-dicarbonyl compounds catalyzed by piperidine is described. The protocol offers facile and efficient synthesis of 5-hydroxy-2H-pyrrol-2-one derivatives from readily available starting materials in high yields. |
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