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Synthesis of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activities |
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| Authors: | Osanai Kumi Huo Congde Landis-Piwowar Kristin R Dou Q Ping Chan Tak Hang |
| Affiliation: | a Department of Applied Biology and Chemical Technology and the Open Laboratory for Chiral Technology, The Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China b The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, MI, USA |
| Abstract: | The total and semi syntheses of (2R,3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, were accomplished. The proteasome inhibition and cytotoxic activities of the synthetic compound and its acetyl derivative were studied and compared with (2R,3R)-epigallocatechin-3-gallate (EGCG), the active component from green tea. |
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