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Solid-phase synthesis of metal-complex containing peptides |
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| Authors: | Georg Dirscherl Paul Hanson |
| Institution: | a Institut für Organische Chemie, Universität Regensburg, Universitätsstrasse 31, D-93040 Regensburg, Germany b Department of Chemistry, Kansas University, Lawrence, KS, USA |
| Abstract: | We report the synthesis of Fmoc protected single amino acid chelates (SAAC) and their metal complexes. The modified amino acids are suitable for solid-phase peptide synthesis. The use of 4-hydroxymethylbenzoic acid AM (HMBA-AM) resin allows the nucleophilic cleavage of the peptide-metal complexes from the resin without decomplexation. |
| Keywords: | Solid-phase peptide synthesis Metal complex Single amino acid chelate |
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