Improved cross-metathesis of acrylate esters catalyzed by 2nd generation ruthenium carbene complexes |
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| Institution: | 1. Nucleus Millennium of Chemical Processes and Catalysis, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile;2. Chemisches Institut der Universität Münster, Corrensstrasse 40, 48149 Münster, Germany;3. Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;4. Universidad Bernardo O Higgins, Departamento de Ciencias Químicas y Biológicas, Laboratorio de Bionanotecnología, General Gana 1702, Santiago, Chile;1. Research and Development, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, PR China;2. School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China;1. Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6;2. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary;3. Egis Pharmaceuticals Plc., Chemical Research Division, PO Box 100, H-1475 Budapest, Hungary;1. Department of Chemistry & Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA;2. Department of Chemistry, The College of New Jersey, 2000 Pennington Road, Ewing, NJ 08628, USA;1. Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science & Technology, Shanghai 200237, China;2. School of Chemistry, University of Edinburgh, West Mains Road, EH9 3JE Edinburgh, UK |
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| Abstract: | The performance of cross-metathesis reactions between acrylate esters and olefins catalyzed by Grubbs catalysts have been enhanced by the simple addition of p-cresol. For example, the efficiency of the cross metathesis reaction between methyl acrylate and 1-decene catalyzed by 2 was significantly increased by addition of p-cresol to the reaction mixture, resulting in increased product yields and E/Z ratios. |
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