Synthesis and crystallographic characterization of multi-donor N-heterocyclic carbene chelating ligands and their silver complexes: Potential use in pharmaceuticals |
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| Affiliation: | 1. Department of Physics, Sindhu Mahavidyalaya, Nagpur 440017, Maharashtra, India;2. Department of Physics, K.Z.S. Science College, Kalmeshwar, Nagpur 441501, Maharashtra, India;3. Department of Physics, RTM Nagpur University, Nagpur 440033, Maharashtra, India;1. V.V. Voevodsky Institute of Chemical Kinetics and Combustion, 3 Institutskaya str., 630090 Novosibirsk, Russian Federation;2. Novosibirsk State University, 2 Pirogova Str., 630090 Novosibirsk, Russian Federation;3. International Tomography Center, 3a Institutskaya str., 630090 Novosibirsk, Russian Federation;4. Department of Environmental Science, Wuhan University, 430072 Wuhan, Hubei, PR China;1. Key Laboratory of Novel Thin-Film Solar Cells, Division of Solar Energy Materials and Engineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China;2. State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources, North China Electric Power University, Beijing 102206, PR China;1. State Key Laboratory of Material Processing and Die & Mould, Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China;2. Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region |
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| Abstract: | The potential for N-heterocyclic carbenes (NHCs) to be used as novel chelating ligands for bio-inorganic pharmaceuticals is discussed. In this paper, we design, synthesize and characterize two NHC precursors, 6 and 7, that we believe have potential for use as metal chelators for pharmaceuticals. The NHC precursors are composed of imidazolium and pyridine rings that would form mixed donor NHCs upon metallation with medicinally relevant metals. The exploration of the silver chemistry of 6 yielded the dimeric silver NHC complex 8[BPh4]2. The study of the silver chemistry of 7 gave 9[1/3(Ag4Br7)] and 10[NO3]3. Complex 9[1/3(Ag4Br7)] appears to be a silver biscarbene charge balanced by a silver bromide anionic cluster. Complex 10[NO3]3 is a trinuclear silver cluster that is stabilized by NHCs and pyridine rings. Silver NHCs have shown themselves to be excellent transmetallation agents for access to other metal NHC systems. It is envisioned that the silver NHCs 8[BPh4]2, 9[1/3(Ag4Br7)] and 10[NO3]3 will readily transfer to medicinally relevant metals, such 105Rh. |
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