Sulfonated N‐heterocyclic carbine‐silver (I) complexes: Synthesis,characterisation and biological evaluation |
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| Authors: | ?eyma Ya?ar Tu?ba Kul Köprülü ?aban Tekin Sedat Ya?ar |
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| Institution: | 1. Faculty of Medicine, Department of Biostatistics and Medical Informatics, In?nü University, Malatya, Turkey;2. Central Research Laboratory, Deparment of Molecular Biology and Genetics, Gaziosmanpa?a University, Tokat, Turkey;3. Catalysis, Research and Applied Center, Department of Chemistry, In?nü University, Malatya, Turkey |
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| Abstract: | The synthesis, characterisation and biological activity of water‐soluble Ag(I)‐NHC complexes, general formula Na(NHC)AgCl] where NHC is a sulfonated and sterically hindered N‐heterocyclic carbene, is reported. The Ag‐NHC complexes (2a–e) were synthesised by reacting the corresponding sulfonated NHC ligands with Ag2O in the presence of NaCl or NaBr in methanol/water (1:1) solution. Synthesised silver (I)‐N‐heterocyclic carbene complexes have been characterised by NMR, micro‐analysis and HRMS spectroscopic methods. The IC50 values of these complexes were determined by a proliferation BrdU enzyme‐linked immunosorbent assay (ELISA) against HeLa (human cervix carcinoma), HT29 (human adenocarcinoma) and L929 (mouse fibroblast) cell lines. These complexes have been highlighted as promising and original platforms for building new types of metalodrug. All new water‐soluble Ag(I) complexes demonstrated remarkable cytotoxic activity against HeLa, HT29 and L929 cell lines. |
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| Keywords: | anticancer activity apoptosis N‐heterocyclic carbene sulfonated N‐heterocyclic carbine water‐soluble silver complex |
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