Three new mixed‐ligand copper(II) complexes containing glycyl‐l‐valine and N,N‐aromatic heterocyclic compounds: Synthesis,characterization, DNA interaction,cytotoxicity and antimicrobial activity |
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| Authors: | Yong‐Yu Qi Ya‐Xian Liu Qian Gan Ya‐Hong Xiong Zong‐Wan Mao Xue‐Yi Le |
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| Institution: | 1. Department of Applied Chemistry, South China Agricultural University, Guangzhou, People's Republic of China;2. School of Chemistry and Chemical Engineering, Sun yat‐sen University, Guangzhou, People's Republic of China |
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| Abstract: | Three novel copper(II) complexes, Cu(Gly‐l ‐Val)(HPBM)(H2O)]·ClO4·H2O ( 1 ), Cu(Gly‐l ‐Val)(TBZ)(H2O)]·ClO4 ( 2 ) and Cu(Gly‐l ‐Val)(PBO)(H2O)]·ClO4 ( 3 ) (Gly‐l ‐Val = glycyl‐l ‐valine anion, HPBM = 5‐methyl‐2‐(2′‐pyridyl)benzimidazole, TBZ = 2‐(4′‐thiazolyl)benzimidazole, PBO = 2‐(2′‐pyridyl)benzoxazole), have been prepared and characterized with elemental analyses, conductivity measurements as well as various spectroscopic techniques. The interactions of these copper complexes with calf thymus DNA were explored using UV–visible, fluorescence, circular dichroism, thermal denaturation, viscosity and docking analyses methods. The experimental results showed that all three complexes could bind to DNA via an intercalative mode. Moreover, the cytotoxic effects were evaluated using the MTT method, and the antimicrobial activity of these complexes was tested against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results showed that the activities are consistent with their DNA binding abilities, following the order of 1 > 2 > 3 . |
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| Keywords: | antimicrobial activity copper(II) complexes cytotoxicity DNA interaction Gly‐l‐Val |
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