Multispectroscopic DNA interaction and Docking studies |
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| Authors: | B Shekhar P Vasantha B Sathish Kumar PV Anantha Lakshmi |
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| Institution: | 1. Department of Chemistry, University College for Women, Osmania University, Hyderabad, Telangana State, India;2. Department of Chemistry, Osmania University, Hyderabad, Telangana State, India;3. Department of Chemistry, University College of Technology, Osmania University, Hyderabad, Telangana State, India |
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| Abstract: | Two new water soluble oxovanadium(IV) complexes with formulae NaVO(his)(met)SO4] (1) and NaVO(gly)(met)SO4] (2), (gly=glycine his=histidine, and met=metformin) were synthesized and characterized by LCMS, UV‐Visible absorption, infrared spectra, magnetic moment, elemental analysis, thermal analysis and electronic spectral studies. The metal center was found in an octahedral geometry. DNA binding interaction of these complexes with CT DNA has been explored by UV‐Visible absorption, fluorescence, viscosity measurements and cleavage studies. Finally the binding of the complexes with CT‐DNA could be surface binding, mainly in the groove binding. The complexes were docked in to B‐DNA sequence, 5’(D*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)‐3’ retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software. |
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| Keywords: | DNA docking groove binding metformin oxovanadium(IV) |
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