Multifunctional triazolylferrocenyl Janus dendron: Nanoparticle stabilizer,smart drug carrier and supramolecular nanoreactor |
| |
Authors: | Li Zhao Qiangjun Ling Xiong Liu Chaodong Hang Qiuxia Zhao Fangfei Liu Haibin Gu |
| |
Institution: | 1. Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, China;2. National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, China |
| |
Abstract: | Owing to their unique broken symmetry, amphiphilic Janus dendrimers and dendons provide fascinating properties for material, biological, pharmaceutical and biomedical applications. The integration of various organometallic moieties into these macromolecules will further offer the opportunity to form complex and intelligent architectures and materials. Here, we report a novel, simple and multifunctional Janus dendron containing redox‐reversible hydrophobic ferrocene (Fc) unit, complexing‐effective 1,2,3‐triazole ligand and biocompatible hydrophilic triethylene glycol termini. Silver and gold nanoparticles were firstly successfully prepared by using the Janus dendron as the reducing agent of Au(III) and Ag(I), and the stabilizer of the corresponding nanoparticles. The redox response of the Fc moiety was then employed to trigger the release of model drug, rhodamine B, encapsulated in supramolecular micelles formed by the self‐assembly of the Janus dendron. Finally, the precise and excellent metal‐complexing ability of the triazole group in this dendron was fully utilized to stabilize a water‐soluble Cu(I) catalyst, forming supramolecular nanoreactors for the catalysis of the copper(I)‐catalyzed azide alkyne cycloaddition click reaction in only water. The multifunctional characteristics of this dendron highlight the potential for organometallic Janus dendrimers and dendrons in the fields of functional materials and nanomedicines. |
| |
Keywords: | CuAAC click chemistry ferrocene chemistry Janus dendrimers and dendrons nanoreactors redox‐responsive silver and gold nanoparticles |
|
|