Application of the Fe3O4@1,10‐phenanthroline‐5,6‐diol@Mn nano‐catalyst for the green synthesis of tetrazoles and its biological performance |
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| Authors: | Davood Habibi Somayyeh Heydari Antonio Gil Mina Afsharfarnia Alireza Faraji Roya Karamian Mostafa Asadbegy |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Chemistry, Bu‐Ali Sina University, Hamedan, Iran;2. Department of Applied Chemistry, Public University of Navarra, Pamplona, Spain;3. Young Researchers & Elite Club, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran;4. Department of Biology, Faculty of Sciences, Bu‐Ali Sina University, Hamedan, Iran |
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| Abstract: | The Fe3O4 magnetic particles were modified with 1,10‐phenanthroline‐5,6‐diol (Phen) and the related Mn complex (Fe3O4@Phen@Mn) synthesized as a heterogeneous catalyst to be used for the one‐pot three‐component synthesis of various tetrazoles. The catalysts were characterized by several methods, such as the elemental analysis, FT‐IR, X‐ray powder diffraction, dispersive X‐ray spectroscopy, scanning electron microscopy, transmission electron microscopy, dynamic light scattering, thermogravimetric‐differential thermal analysis, vibrating sample magnetometer and X‐ray photoelectron spectroscopy. In addition, the antioxidant and antibacterial activities of the catalyst and its Phen ligand were in vitro screened with 2,2‐diphenyl‐1‐picrylhydrazyl by free radical scavenging methods. Results showed that the synthesized compounds possess strong antioxidant activity (IC50; 0.172 ± 0.005 mg ml?1) as well as a good antibacterial potential in comparison to standards. |
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| Keywords: | 1 10‐phenanthroline‐5 6‐diol biological performance catalyst Fe3O4 magnetic particle tetrazoles |
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