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Trimethylsilyl isothiocyanate (TMSNCS): an efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles
Authors:Dinneswara Reddy GudaTengjiao Wang  Hyeon Mo ChoMyong Euy Lee
Affiliation:Department of Chemistry & Medical Chemistry, College of Science and Technology, Research & Education Center for Advanced Silicon Materials, Yonsei University, Wonju, Gangwon-do 220-710, South Korea
Abstract:A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4-triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields.
Keywords:Mercapto-1,2,4-triazoles   Trimethylsilyl isothiocyanate   Carboxylic acid hydrazides
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