Trimethylsilyl isothiocyanate (TMSNCS): an efficient reagent for the one-pot synthesis of mercapto-1,2,4-triazoles |
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Authors: | Dinneswara Reddy GudaTengjiao Wang Hyeon Mo ChoMyong Euy Lee |
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Affiliation: | Department of Chemistry & Medical Chemistry, College of Science and Technology, Research & Education Center for Advanced Silicon Materials, Yonsei University, Wonju, Gangwon-do 220-710, South Korea |
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Abstract: | A mild, convenient, and efficient one-pot synthesis of mercapto-1,2,4-triazoles is described. Various hydrazides efficiently reacted with trimethylsilyl isothiocyanate (TMSNCS) under basic condition to give mercapto-1,2,4-triazoles in high yields. |
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Keywords: | Mercapto-1,2,4-triazoles Trimethylsilyl isothiocyanate Carboxylic acid hydrazides |
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