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Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes |
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| Authors: | Xin Teng Aleksandr Kasatkin Yasufumi Kawanaka Sentaro Okamoto Fumie Sato |
| Affiliation: | Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226, Japan |
| Abstract: | Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and a Ti(O-i-Pr)4/2i-PrMgCl reagent, which, in turn, react with aldehydes regio- and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields. |
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