Cross-Coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors |
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| Authors: | Dr Aiichiro Nagaki Yuya Moriwaki Suguru Haraki Akira Kenmoku Naofumi Takabayashi Atsushi Hayashi Prof Dr Jun-Ichi Yoshida |
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| Institution: | 1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727;2. The Research Association of Micro Chemical, Process Technology (MCPT), Nishikyo-ku, Kyoto 615-8510 (Japan) |
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| Abstract: | The use of Pd catalysts that contained a carbene ligand, such as PEPPSI-SIPr, speeded up the Murahashi coupling of ArLi with ArBr, by enabling its integration with the Br/Li exchange of ArBr with BuLi in flow. Space integration realized the rapid cross-coupling of two different ArBr substrates. However, the cross-coupling reaction with vinyl halides could not be achieved under similar conditions. Pd(OAc)2 was an effective catalyst, and the space integration of the Br/Li exchange of ArBr with BuLi and the Murahashi coupling with vinyl halides was successfully achieved. |
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| Keywords: | arenes cross-coupling halides lithiation microreactors |
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