A selenium analogue of firefly d-luciferin with red-shifted bioluminescence emission |
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| Authors: | Conley Nicholas R Dragulescu-Andrasi Anca Rao Jianghong Moerner W E |
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| Institution: | Department of Chemistry, Stanford University, Stanford, CA 94305-5080 (USA). |
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| Abstract: | A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600?nm and is suitable for bioluminescence imaging studies in living subjects. |
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| Keywords: | bioluminescence chalcogens imaging agents luciferase selenium |
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