示波非水电位滴定法及其在药物分析上的应用

本文介绍一种非水电位滴定指示终点的新方法,即用阴极射线示波器取代常用的测量电压的装置。将样品溶于含适量醋酐的冰醋酸中,加入适量的醋酸汞,用微铂球电极作指示电极,甘汞电极作参比电极,它们直接与阴极射线示波器的y轴和接地相连,两电极间无任何外加电压,滴定终点时两电极间电位差(△E)产生瞬时突变,示波器荧光屏上荧光点的跳移指示滴定终点。用本法测定了11种有机碱药物,和法定方法作了比较,结果无显著性差异。

Nonaqueous Oscillopotentiometric Titration and its Application in Pharmaceutical Analysis

A new technique of end point indication in nonaqueous potentioroetric titration was presented. A cathode-ray oscillograph was used to replace the usual voltagemeasuring instrument. The sample was dissoved in the glacial acetic acid containing some acetic anhydride and mercury acetate and determined with 0.1 mol/L perchloric acid standard solution, using microplatinum billet electrode as indicator electrode and calomel electrode as reference electrode. The sudden jumping of a fluorescent spot on the fluorescent screen indicates the end point of titration. This method of indication can response the transitory potential difference of two electrodes, the end point is directly visual and sensitive much better than the usual method. We have used this method to determine 11 organic basic drugs and obtained satisfactory results.