Macrocycloadditions leading to conformationally restricted small molecules |
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| Authors: | Looper Ryan E Pizzirani Daniela Schreiber Stuart L |
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| Affiliation: | Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02138, USA. |
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| Abstract: | ![]()
[reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents. |
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