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| 由D-(-)-核糖合成Aigialomycin D C2'—C7'片段的简捷方法 | |
| 引用本文： | 张洪奎,陈伟强. 由D-(-)-核糖合成Aigialomycin D C2'—C7'片段的简捷方法[J]. 高等学校化学学报, 2007, 28(4): 689-691 |
| 作者姓名： | 张洪奎 陈伟强 |
| 作者单位： | 厦门大学化学系,厦门,361005 |
| 摘 要： | 报道以D-(-)-核糖为起始原料合成Aigialomycin D的关键手性中间体C的一种简便方法. 化合物C是未见报道的新手性化合物. |
| 关 键 词： | Aigialomycin D D-(-)-核糖 合成 |
| 文章编号： | 0251-0790（2007）04-0689-03 |
| 收稿时间： | 2006-05-14 |
| 修稿时间： | 2006-05-14 |
A Concise Synthesis of C2'-C7' Fragment of Aigialomycin D |
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| ZHANG Hong-Kui,CHEN Wei-Qiang. A Concise Synthesis of C2'-C7' Fragment of Aigialomycin D[J]. Chemical Research In Chinese Universities, 2007, 28(4): 689-691 | |
| Authors: | ZHANG Hong-Kui CHEN Wei-Qiang |
| Affiliation: | Department of Chemistry, Xiamen University, Xiamen 361005, China |
| Abstract: | Aigialomycin D(1) possesses a potent antitumor activity and anti-malarial activity. In this paper a concise route for the synthesis of the key C2'—C7' fragment of aigialomycin D by using D-(-)-ribose was described. The fragment was synthesized in six steps in 37.2% overall yield, including protection of the vicinal diol, Wittig reaction of the lactol, hydrogenation, oxidative cleavage of the diol, terminal olefination and selective reduction of the ester. This work lays a good foundation for the total synthesis of aigialomycin D. |
| Keywords: | Aigialomycin D D-(-)-Ribose')" href=" #" > D-(-)-Ribose Synthesis |
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