| (7R,10S)-Boivinianin B的不对称合成 |
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| 引用本文： | 许柏岩,宋娜,李文泽,辛志君,李瀛.(7R,10S)-Boivinianin B的不对称合成[J].高等学校化学学报,2009,30(7):1329-1331. |
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| 作者姓名： | 许柏岩 宋娜 李文泽 辛志君 李瀛 |
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| 作者单位： | 1. 兰州大学功能有机分子化学国家重点实验室, 兰州 730000;
2. 九洲药业股份有限公司, 台州 318000 |
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| 摘 要： | 报道了一种基于Dehydro-α-curcumene(4)为关键中间体, 以Sharpless不对称双羟化反应和碘催化的分子内环化成醚反应为关键步骤, 构建2,2,5位三取代的四氢呋喃骨架的方法, 完成了(7R,10S)-Boivinianin B(1)的不对称合成. 合成路线简捷, 对此类化合物的合成有一定的借鉴意义.
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| 关 键 词： | 不对称合成 (7R 10S)-Boivinianin B 碘化成醚反应 |
| 收稿时间： | 2009-01-13 |
First Asymmetric Synthesis of (7R,10S)-Boivinianin B |
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| XU Bo-Yan,SONG Na,LI Wen-Ze,XIN Zhi-Jun,LI Ying.First Asymmetric Synthesis of (7R,10S)-Boivinianin B[J].Chemical Research In Chinese Universities,2009,30(7):1329-1331. |
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| Authors: | XU Bo-Yan SONG Na LI Wen-Ze XIN Zhi-Jun LI Ying |
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| Institution: | 1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;
2. Jiuzhou Pharmaceutical Co., Ltd., Taizhou 318000, China |
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| Abstract: | (7R,10S)-Boivinianin B(1),a naturally occurring sesquiterpene which has a synthetically challenging 2,2,5-tri-substituted tetrahydrofuran skeleton,was isolated from Laurencia tristicha and Cipadessa boiviniana. First asymmetric synthesis of the title compound was developed by sharpless asymmetric dihydroxyation to generate a stereocenter which as a chiral pool in the next procedure and an intramolecular iodoetherification to construct the tetrahydrofuran skeleton. The method developed here will be a useful ... |
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| Keywords: | (7R 10S)-Boivinianin B |
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