Atropoisomeric quinolinium salt promoting the access to both enantiomeric forms of methyl mandelate: a versatile NADH mimic |
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| Authors: | Vasse Jean-Luc Levacher Vincent Bourguignon Jean Dupas Georges |
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| Institution: | Laboratoire de Chimie Organique Fine et Hétérocyclique, I.R.C.O.F, 1, rue Tesnieres, Mont-Saint-Aignan, France 76131. |
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| Abstract: | Asymmetric reduction of methyl benzoylformate by a new NADH mimic is reported; depending on the hydride source used to reduce the NAD+ precursor, NADH mimics so obtained lead to an inversion of enantioselectivity, affording either (R)-methyl mandelate in 88% ee or (S)-methyl mandelate in 78% ee. |
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