| Synthesis Hexadecyl 3-{4-[2-Hydroxy-3（isopropylamino）propoxy]phenyl}propionate as Potential Ligand for Liposome Targeting to Ischemic Myocardium |
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| 作者姓名： | Yan Li HAO Ying Jie DENG Yan CHEN You Cai HU |
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| 作者单位： | [1]Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016 [2]Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050 |
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| 摘 要： | Novel hexadecyl 3- { 4-2-hydroxy-3（isopropylamino）propoxy]phenyl }propionate （HPP）was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined. The structure of HPP was characterized by IH NMR, 1R and MS. The amount of cardiomyocytes uptake of HPP-liposome was 3.9-fold higher than plain-liposome, and the increase was 6.2-fold when hypoxia happens. It indicated that HPP was a potential ligand for liposome targeting to ischemic myocardium.
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| 关 键 词： | 4-2-羟基-3-苯基丙酸盐 配合基 合成方法 HPP 脂质体 |
| 收稿时间： | 2004-09-23 |
Synthesis Hexadecyl 3-{4-[2-Hydroxy-3(isopropylamino)propoxy]phenyl}propionate as Potential Ligand for Liposome Targeting to Ischemic Myocardium |
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| Yan Li HAO Ying Jie DENG Yan CHEN You Cai HU.Synthesis Hexadecyl 3-{4-[2-Hydroxy-3(isopropylamino)propoxy]phenyl}propionate as Potential Ligand for Liposome Targeting to Ischemic Myocardium[J].Chinese Chemical Letters,2005,16(8):1004-1006. |
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| Authors: | Yan;Li;HAO;Ying;Jie;DENG;Yan;CHEN;You;Cai;HU |
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| Abstract: | Novel hexadecyl 3-{4-2-hydroxy-3(isopropylamino)propoxy]phenyl}propionate (HPP) was synthesized and its effect on delivery of liposomes into cultured cardiomyocytes was examined. The structure of HPP was characterized by 1H NMR, IR and MS. The amount of cardiomyocytes uptake of HPP-liposome was 3.9-fold higher than plain-liposome, and the increase was 6.2-fold when hypoxia happens. It indicated that HPP was a potential ligand for liposome targeting to ischemic myocardium. |
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| Keywords: | Hexadecyl 3-{4-[2-hydroxy-3(isopropylamino)propoxy]phenyl}propionate liposome targeting ischemic myocardium |
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