| 手性铝试剂促进的β-环氧醇动力学拆分研究 |
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| 引用本文： | 王少华,王飞,张辅民,樊春安,涂永强,任世阔.手性铝试剂促进的β-环氧醇动力学拆分研究[J].有机化学,2005,25(10):1302-1305. |
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| 作者姓名： | 王少华 王飞 张辅民 樊春安 涂永强 任世阔 |
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| 作者单位： | 兰州大学化学化工学院,功能有机分子化学国家重点实验室,兰州,730000 |
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| 摘 要： | 首次以手性联萘酚修饰的三乙基铝为催化剂对消旋的β-环氧醇的动力学拆分进行了研究, 初步研究结果表明其回收原料的ee值可达60%. 同时研究了不同条件下三乙基铝与手性配体形成的手性路易斯酸对β-环氧醇的动力学拆分的影响, 并探讨了在三乙基铝催化下的反应机理.
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| 关 键 词： | 三乙基铝 β-环氧醇 手性联萘酚 动力学拆分 |
| 收稿时间： | 12 16 2004 12:00AM |
| 修稿时间： | 04 26 2005 12:00AM |
Kinetic Resolution ofβ-Hydroxy Epoxides Promoted by Chiral Aluminium Reagents |
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| WANG,Shao-Hua,WANG,Fei,ZHANG,Fu-Min,FAN,Chun-An,TU,Yong-Qiang,REN,Shi-Kuo.Kinetic Resolution ofβ-Hydroxy Epoxides Promoted by Chiral Aluminium Reagents[J].Chinese Journal of Organic Chemistry,2005,25(10):1302-1305. |
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| Authors: | WANG Shao-Hua WANG Fei ZHANG Fu-Min FAN Chun-An TU Yong-Qiang REN Shi-Kuo |
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| Institution: | (State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou Univer-sity, Lanzhou 730000) |
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| Abstract: | The first kinetic resolution of β-hydroxy epoxides has been studied through chiral aluminium reagents, which gave the recovered starting material with 60% ee. Various conditions were explored for the kinetic resolution of β-hydroxy epoxide by chiral aluminium reagents. A possible mechanism was proposed for the reaction by aluminium reagent. |
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| Keywords: | triethylaluminium β-hydroxy epoxide chiral BINOL kinetic resolution |
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