A 2D graphical representation of DNA sequence based on dual nucleotides and its application

From the perspective of the neighboring dual nucleotides, we introduce a novel 2D graphical representation of DNA sequences based on the magic circle, which correspond to 16 dual nucleotides. So, we can reduce a DNA sequence into a plot set in two‐dimensional space and get a two‐component vector relatively to the introduced covariance matrix. The utility of our approach can be illustrated by the examination of similarities/dissimilarities among the complete coding sequences of β‐globin gene belonging to 11 species. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2009