An efficient high-yield synthesis of D-ribo-phytosphingosine |
| |
Authors: | Lombardo Marco Capdevila Montse Guiteras Pasi Filippo Trombini Claudio |
| |
Institution: | Dipartimento di Chimica G. Ciamician, Università di Bologna, via Selmi 2, 40126, Bologna, Italy. marco.lombardo@unibo.it |
| |
Abstract: | Structure: see text] 4R-4alpha(S),5alpha]]-2,2-Dimethyl-4-(2-oxo-5-vinyl1,3]dioxolan-4-yl)oxazolidine-3-carboxylic acid tert-butyl ester 5a, obtained in excellent yield and diastereoselectivity by the alpha-hydroxyallylation of the Garner aldehyde (4), is exploited in a novel high-yield synthesis of D-ribo-phytosphingosine (8), using microwave-enhanced cross metathesis as the key step in the chain elongation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|