Heterogeneous diastereoselective hydrogenation of pyridine and corresponding enamine covalently bound to pantolactone |
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| Authors: | Najiba Douja, Raluca Malacea, Mich le Besson,Catherine Pinel |
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| Affiliation: | Institut de Recherches sur la Catalyse-CNRS, 2 Avenue Albert Einstein, 69626, Villeurbanne Cedex, France |
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| Abstract: | The diastereoselective hydrogenation of 2-methyl nicotinic acid covalently bound to pantolactone was studied over supported metallic catalysts. With this chiral auxiliary, a two-steps reaction was observed with formation of tetrahydropyridine intermediate. The influence of different reaction parameters on the diastereoselectivity of the hydrogenation of pyridine and enamine substrates was studied. |
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| Keywords: | Hydrogenation Pyridine Pantolactone Nicotinic |
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