Tetrazoles: L. Microwave-activated alkylation of 5-aryltetrazoles and 1-substituted tetrazole-5-thiones with 1,3-dibromo-2,2-bis(bromomethyl)propane |
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| Authors: | M. V. Zatsepina A. Hrabalek T. V. Artamonova G. I. Koldobskii |
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| Affiliation: | (1) St. Petersburg State Institute of Technology, Moskovskii pr. 26, St. Petersburg, 190013, Russia;(2) Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove, 50005, Czech Republic |
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| Abstract: | Alkylation of 5-aryltetrazoles and 1-substituted tetrazole-5-thiones with 1,3-dibromo-2,2-bis(bromomethyl)propane in dimethylformamide in the presence of sodium hydroxide leads to the formation of tetrakis(5-aryltetrazol-2-ylmethyl)methanes and tetrakis(1-R-tetrazol-5-ylsulfanylmethyl)methanes, respectively. Microwave activation considerably shortens the reaction time and increases the yield. |
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