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Diastero- and enantioselective intramolecular carbometalation reaction |
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| Authors: | Rozalia Unger Ilan Marek |
| Affiliation: | a Mallat Family Laboratory of Organic Chemistry, Schulich Faculty of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, Technion-Israel Institute of Technology, 32000 Haifa, Israel b Department of Chemistry, University of Pittsburgh, PA 15260, USA |
| Abstract: | The zinc-catalyzed addition of various alkynes to acylsilanes followed by a Zn-Brook rearrangement and either the Zn-ene-allene or Zn-yne-allene cyclization led to the enantio- and diastereoselective formation of carbocycles in a single-pot operation. |
| Keywords: | Brook rearrangement Zn-ene-allene cyclization Enantioselective alkynylation Carbometalation Asymmetric catalysis |
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