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A convenient synthesis of deuterium labeled tertiary aliphatic nitro ketones and nitriles - starting materials for preparation of deuterated cyclic nitrones, isomeric hydroxylamines, and corresponding C-nitroso compounds |
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| Authors: | Karol Grela Leszek Konopski |
| Affiliation: | a Department of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland b Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland c Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland |
| Abstract: | Tertiary aliphatic β- and γ-nitro nitriles and ketones deuterated in (several) selected positions had been synthesized. The deuterated nitro compounds served as a starting material for the corresponding deuterium labeled nitrones or hydroxylamines (reducing with aluminum amalgam). Further oxidation of the last two groups of compounds with sodium periodate or m-CPBA afforded the relevant deuterated tertiary C-nitroso compounds. |
| Keywords: | Deuterated nitro ketones Deuterated nitro nitriles Deuterated hydroxylamines Deuterated cyclic nitrones Deuterated nitroso ketones Deuterated nitroso nitriles Deuterium labeling |
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