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Synthesis of triazole analogues of the nanaomycin antibiotics using ‘click chemistry’ |
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| Authors: | Kris Rathwell Jonathan Sperry Margaret A. Brimble |
| Affiliation: | a Department of Chemistry, University of Auckland, 23 Symonds Street, Auckland, New Zealand b Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand |
| Abstract: | A series of triazole analogues of the nanaomycin family of antibiotics have been prepared using a ‘click’ dipolar cycloaddition of a naphthalene azide to various alkynes, followed by oxidation to the desired pyranonaphthoquinones. |
| Keywords: | Pyranonaphthoquinone &lsquo Click chemistry&rsquo Triazole Nanaomycin |
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