Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction |
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| Authors: | Kazuhiro Higuchi |
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| Affiliation: | Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan |
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| Abstract: | A novel preparative method for 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones through the oxidation of 2-arylindoles followed by a Mannich-type reaction with carbon nucleophiles is described. |
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| Keywords: | Oxidation of indole Mannich-type reaction 2,2-Disubstituted 1,2-dihydro-3H-indol-3-one C-Acyliminium intermediate |
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