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Globular carbosilane dendrimers with mannose groups at the periphery: synthesis, characterization and toxicity in dendritic cells |
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| Authors: | Paula Ortega,Ma Jesú s Serramí a,Ma Angeles Muñ oz-Ferná ndez,F. Javier de la Mata,Rafael Gó mez |
| Affiliation: | a Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain b Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain c Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain |
| Abstract: | A synthetic strategy has been developed for the preparation of new globular carbosilane dendrimers with mannose groups at the periphery. It consists of hydrosilylation reaction of allyl tetraacetylmannose with carbosilane dendrimers containing monohydrosilane end groups and the subsequent deacetylation reaction. Evaluation of dendrimer toxicities in dendritic cells by MTT assay were carried out, and evidence a good biocompatibility. |
| Keywords: | Dendrimers Mannose Carbosilane Dendritic cells |
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