Clean one-pot synthesis of 1,2,4-oxadiazoles under solvent-free conditions using microwave irradiation and potassium fluoride as catalyst and solid support |
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| Authors: | Shahnaz Rostamizadeh Hamid Reza Ghaieni Reza Aryan |
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| Affiliation: | a Department of Chemistry, K.N.Toosi University of Technology, PO Box 15875-4416, Tehran, Iran
b Faculty of Material and Chemical Engineering, Malek Ashtar University of Technology, Tehran, Iran |
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| Abstract: | Potassium fluoride was found to be an efficient catalyst and solid support for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. In this work, a one-pot method for the synthesis of these compounds from the reaction of nitriles with hydroxylamine hydrochloride and acyl chloride in the presence of potassium fluoride under solvent-free conditions using microwave irradiation has been developed. The advantages of using potassium fluoride as a solid support in comparison to conventional solid supports are simple operation and convenient separation of the products. |
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| Keywords: | 1,2,4-Oxadiazole Amidoxime Nitrile Potassium fluoride Solvent free |
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