Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte

Authors:	Moira L. Bode Samson Y. Gebretnsae

Affiliation:	^a Discovery Chemistry, CSIR Biosciences, Private Bag X2, Modderfontein 1645, South Africa ^b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom ^c Department of Chemistry, University of Pretoria, Lynnwood Road, Hillcrest, Pretoria 0002, South Africa

Abstract:	The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the ¹³C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.

Keywords:	Pavettamine Gousiekte Stereoselective synthesis Polyamine Pavetta harborii β-Ketosulfoxide reduction
本文献已被 ScienceDirect 等数据库收录！