Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis |
| |
| Authors: | Alessandro Massella Giulia D'Intino Mercedes Fernández Sandra Sivilia Luca Lorenzini Silvia Giatti Roberto C Melcangi Laura Calzà Luciana Giardino |
| |
| Affiliation: | (1) Health Sciences and Technology - Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Italy;(2) Department of Veterinary Medicine, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Italy;(3) Dept. of Endocrinology, Pathophysiology and Applied Biology - Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milano, Italy |
| |
| Abstract: | Background Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in gender-related differences. The present study describes possible cellular- and molecular-involved markers which are differentially regulated in male and female rats and result in gender-dependent EAE evolution and progression. Attention was focused on markers of myelination (MBP and PDGFαR) and neuronal distress and/or damage (GABA synthesis enzymes, GAD65 and GAD67, NGF, BDNF and related receptors), in two CNS areas, i.e. spinal cord and cerebellum, which are respectively severely and mildly affected by inflammation and demyelination. Tissues were sampled during acute, relapse/remission and chronic phases and results were analysed by two-way ANOVA. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
