Near‐Infrared Triggered Decomposition of Nanocapsules with High Tumor Accumulation and Stimuli Responsive Fast Elimination |
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| Authors: | Tiancong Zhao Peiyuan Wang Prof. Dr. Qin Li Dr. Areej Abdulkareem Al‐Khalaf Prof. Dr. Wael N. Hozzein Prof. Dr. Fan Zhang Prof. Dr. Xiaomin Li Prof. Dr. Dongyuan Zhao |
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| Affiliation: | 1. Department of Chemistry and Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, (2011-iChEM), Fudan University, Shanghai, P. R. China;2. Queensland Micro- and Nanotechnology Centre, Griffith University, Brisbane, QLD, Australia;3. Biology Department, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia;4. Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia;5. Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt |
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| Abstract: | A near‐infrared (NIR) induced decomposable polymer nanocapsule is demonstrated. The nanocapsules are fabricated based on layer‐by‐layer co‐assembly of azobenzene functionalized polymers and up/downconversion nanoparticles (U/DCNPs). When the nanocapsules are exposed to 980 nm light, ultraviolet/visible photons emitted by the U/DCNPs can trigger the photoisomerization of azobenzene groups in the framework. The nanocapsules could decompose from large‐sized nanocapsule to small U/DCNPs. Owing to their optimized original size (ca. 180 nm), the nanocapsules can effectively avoid biological barriers, provide a long blood circulation (ca. 5 h, half‐life time) and achieve four‐fold tumor accumulation. It can fast eliminate from tumor within one hour and release the loaded drugs for chemotherapy after NIR‐induced dissociation from initial 180 nm capsules to small 20 nm U/DCNPs. |
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| Keywords: | core– shell structure drug delivery nanocapsules nanoparticles upconversion |
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