Functional Hydride Transfer by a Thiolate‐Containing Model of Mono‐Iron Hydrogenase featuring an Anthracene Scaffold |
| |
| Authors: | Spencer A Kerns Anne‐Clarisse Magtaan Pisey R Vong Michael J Rose |
| |
| Institution: | Department of Chemistry, The University of Texas at Austin, Austin, TX, USA |
| |
| Abstract: | We report the synthesis, X‐ray structure and functional biomimetic activity of a model complex of mono‐iron hydrogenase (Hmd). To achieve the desired biomimetic fac‐CNS(thiolate) ligation motif, an anthracene framework is used to provide the requisite donors in a single chelate. A bulky aryl thiolate (ortho dimethylphenyl) is included to achieve mononuclearity. In addition to exhibiting structural (X‐ray) and spectroscopic (NMR, IR) similarity to the enzyme, the complex is competent for H2 activation (heterolysis) and hydride transfer to a model substrate—mimicking the functional behavior of the enzyme in a biomimetic CNS coordination sphere for the first time. |
| |
| Keywords: | biomimetic hydride transfer hydrogen activation mono-iron hydrogenase scaffold chelate |
|
|
