MR visible localization device for radiographic-pathologic correlation of surgical specimens |
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| Institution: | 1. Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA;2. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany;3. Clinic of Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland;4. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA;5. Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA;6. Pathology Clinic, University of Wisconsin-Madison, Madison, WI, USA;7. Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA;8. Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, USA;9. Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA;1. Department of Radiology and Imaging Sciences, University of Utah, 729 Arapeen Drive, Salt Lake City, UT 84108, USA;2. Department of Bioengineering, University of Utah, 36 S Wasatch Drive, Rm 3100, Salt Lake City, UT 84112, USA;3. Siemens Medical Solutions, Inc., 660 First Avenue, 4th Floor, New York, NY 10016, USA;4. Siemens Medical Solutions, Inc., 729 Arapeen Drive, Salt Lake City, UT 84108, USA;5. Division of Nephrology, Department of Internal Medicine, University of Utah, 30 N 1900 E, Rm 4R312, Salt Lake City, UT 84132, USA;1. Department of Radiology, University of Cambridge, United Kingdom;2. GE Healthcare, Amersham, United Kingdom;3. GE Healthcare, Waukesha, WI, USA;4. Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, United Kingdom;1. Department of Biomedical Engineering, Columbia University, Biomedical Engineering, 630 West 168th Street, Physicians and Surgeons 19-418, Manhattan, NY 10032, United States;2. Department of Radiology, Columbia University Medical Center, 177 Ft. Washington Ave. Milstein Bldg Room 3-124B, New York, NY 10032, United States;1. Department of Medical Imaging, Tongji Hospital, Tongji University, No. 389, Xincun Road, Putuo District, Shanghai 200065, China;2. Department of Medical Imaging, Renji Hospital, Medical School of Jiaotong University, No. 160, Pujian Road, Pudong District, Shanghai 200127, China;1. Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland;2. Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland;1. Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA;3. Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37232, USA;4. AstraZeneca, Alderley Park, MACCLESFIELD, Cheshire SK10 4TG, United Kingdom;5. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232, USA;6. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA;7. Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA |
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| Abstract: | PurposeThe detection of small parenchymal hepatic lesions identified by preoperative imaging remains a challenge for traditional pathologic methods in large specimens. We developed a magnetic resonance imaging (MRI) compatible localization device for imaging of surgical specimens aimed to improve identification and localization of hepatic lesions ex vivo.Materials and methodsThe device consists of two stationary and one removable MR-visible grids lined with silicone gel, creating an orthogonal 3D matrix for lesion localization. To test the device, five specimens of swine liver with a random number of lesions created by microwave ablation were imaged on a 3 T MR scanner. Two readers independently evaluated lesion coordinates and size, which were then correlated with sectioning guided by MR imaging.ResultsAll lesions (n = 38) were detected at/very close to the expected localization. Inter-reader agreement of lesion localization was almost perfect (0.92). The lesion size estimated by MRI matched macroscopic lesion size in cut specimen (± 2 mm) in 34 and 35, respectively, out of 38 lesions.ConclusionUse of this MR compatible device for ex vivo imaging proved feasible for detection and three-dimensional localization of liver lesions, and has potential to play an important role in the ex vivo examination of surgical specimens in which pathologic correlation is clinically important. |
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