3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profile/view ordering: Feasibility of right ventricular myocardial damage assessment using a swine animal model |
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| Institution: | 1. Department of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States;2. Department of Surgery, Section of Cardiothoracic Surgery, The University of Chicago, Chicago, IL, United States;3. Department of Radiology, The University of Chicago, Chicago, IL, United States;4. Philips, Gainesville, FL, United States.;1. Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA;2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA;3. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA;4. UCSF/UC Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA, USA;5. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA;1. Mayo Graduate School, Biomedical Engineering and Physiology Track, Mayo Clinic, Rochester, Minnesota, USA;2. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA;3. Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA;1. Department of Radiation Sciences, Umeå University, Umeå, Sweden;2. Department of Radiology, Uppsala University Hospital, Uppsala, Sweden;3. Applied Science Laboratory, GE Healthcare, Uppsala, Sweden |
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| Abstract: | AimsTo develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV).Methods and resultsA k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed. 8 pigs were surgically prepared with cardiac patch implantation in the RV, followed in 60 days by 1.5 T MRI. LGE with Phase-Sensitive Inversion Recovery (PSIR) were performed as follows: 1) 2DBH using pneumatic control, and 2) navigator-gated, 3D free-breathing (3DFB)-CP-LGE with slice-tracking. The animal heart was excised immediately after cardiac MR for scar volume quantification. RV scar volumes were also delineated from the 2DBH and 3DFB-CP-LGE images for comparison against the surgical standard. Apparent scar/normal tissue signal-to-noise ratio (aSNR) and contrast-to-noise ratio (aCNR) were also calculated.3DFB-CP-LGE technique was successfully performed in all animals. No difference in aCNR was noted, but aSNR was significantly higher using the 3D technique (p < 0.05). Against the surgical reference volume, the 3DFB-CP-LGE-derived delineation yielded significantly less volume quantification error compared to 2DBH-derived volumes (15 ± 10% vs 55 ± 33%; p < 0.05).ConclusionCompared to conventional 2DBH-LGE, 3DFB-LGE acquisition using CENTRA-PLUS provided superior scar volume quantification and improved aSNR. |
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